Belinostat (PXD101)

Belinostat (PXD101)

Author: ApexBio

spu:

A4096

CAS:

414864-00-9

purity:

0.9804

shortsummary:

Hydroxamate-type HDAC inhibitor

JMJD2 inhibitor Description

Synonyms:

PXD-101, PXD 101, PX105684, PX-105684

a 83 References

Formula:

C15H14N2O4S

M.Wt:

318.35

Chemical Name:

(E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide

SMILES:

C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO

Solubility:

insoluble in H2O; ≥15.92 mg/mL in DMSO; ≥44.1 mg/mL in EtOH with ultrasonic

Storage:

Store at -20°C

Physical Appearance:

A solid

DeliveryTime:

In stock

108321-42-2 Description

ShippingType:

Blue ice

description:

Belinostat (also known as PXD101) is a novel and potent hydroxamate-type inhibitor of histone deacetylase (HDAC) that inhibits the activity of HDAC in Hela cell extracts with 50% inhibition concentration IC₅₀ value of 27 nM. Belinostat has been found to significantly increase the acetylation of histones H3 and H4 and exerts cytotoxicity in a wide range of tumor cell lines. In the treatment of urothelial carcinoma cell lines, belinostat dose-dependently inhibits proliferation in 5637, T24, J82 and RT4 cells with IC₅₀ values of 1.0 μM, 3.5 μM, 6.0 μM and 10 μM respectively; while, in prostate cancer cell lines, it inhibits cancer cell growth with IC₅₀ values ranging from 0.5 to 2.5 μM.

related websites:

APExBIO Technology LLC is a premier provider of Small Molecule Inhibitors/Activators, Compound Libraries, Peptides, Assay Kits, Fluorescent Labels, Enzymes, Modified Nucleotides, mRNA synthesis and various tools for Molecular Biology. We carry a broad product line in over 1129 different research areas such as cancer, immunology, neurosciences, apoptosis and epigenetics etc. Based in USA (Houston, Texas), we have been serving the needs of customers across the world.